Next Generation Glaucoma Medications and Surgeries

Next Generation  Glaucoma Medications and Surgeries


So what’s in the pipeline? Next-generation medications and surgeries
in the pipe line. Medications
Quickly, the medications that are—that you’re going to see—some of these are already available
say in Japan and elsewhere but hopefully we’ll see these in the US. There’s essentially three new classes of
medications: The Rho-Kinase or the ROCK inhibitors—they
open the drain by relaxing the trabecular meshwork. The Norepinephrine Transporter Inhibitors
or the NET Medications—they “turn on the faucet”. There’s one an FDA trials right now, which
is a ROCK/NET. So it uses both of these. Just like the alpha-2 agonists, you could
potentially get both a reduction in the flow (reduction in the production of fluid) as
well as an improvement in the outflow—so that’s very exciting. Adenosine Receptor Agonists
They work by increasing the outflow through the trabecular meshwork. Modified Prostaglandin Analogs
Now, these are basically Prostaglandin Analogue plus a Nitric Oxide. So they’re generally (you can think of some
of these as) Prodrugs. They enter the anterior chamber, they’re
split up into the prostaglandin and a nitric oxide. Nitric oxide relaxes the trabecular meshwork
and Schlemm’s canal increasing outflow.

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